Interacting populations affecting proliferation of leukemic cells in culture.

Mesenchymal Stem Cells Do Not Suppress Lymphoblastic Leukemic Cell Line Proliferation

Background: Several studies have demonstrated the immunosuppresive effects of mes-enchymal stem cells (MSCs) in allogeneic or mitogenic interactions. Cell-cell contact inhibition and secretion of suppressive soluble factors have been suggested in this re-gard. Objective: To investigate if adipose derived MSCs could inhibit Jurkat lym-phoblastic leukemia T cell proliferation during coculture. Me...

Studies of leukemic cell populations in culture.

A suspension culture technique for the study of peripheral blood cells from patients with leukemia is described. Cells from patients in relapse were preserved by freezing with dimethylsulfoxide at -70#{176}C to ensure the availability of the same population of cells for repeated experiments of varying designs. Cells from one AML patient proliferated only in the presence of phytohemagglutinin (P...

Interacting cell populations affecting granulopoietic colony formation by normal and leukemic human marrow cells.

Sensitivity of Human Leukemic Cells to Carvedilol

Background and Objective: Carvedilol, a non-specific β-blocker, has been used for treatment of hypertension, stroke and congestive heart failure. The therapeutic effects of β blockers in cancer patients have been shown. Carvedilol has considerable anti-inflammatory, anti-tumor and anti-angiogenic properties. In this study, the effects of carvedilol on proliferation of human U937 and Molt-4 leuk...

Assessment of Culture Condition and In Vitro Colonization Ability of Human Spermatogonial Stem Cells: A Review Article

Spermatogenesis is a highly complex and regulated process in which germ stem cells differentiate into spermatozoa. These stem cells, called spermatogonial stem cells (SSCs), are in the base of seminiferous tubules and have the ability of self-renewal and differentiation into functional germ cells. Due to this ability, SSCs can restore spermatogenesis after testicular damage caused by cytotoxic ...